Hepatitis C virus infection is associated with endothelial dysfunction in HIV/hepatitis C virus coinfected patients

AIDS. 2010 Aug 24;24(13):2059-67. doi: 10.1097/QAD.0b013e32833ce54d.

Abstract

Objective: To quantify serum levels of intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in HIV/HCV coinfected patients to examine their association with several clinical and epidemiological characteristics and the therapeutic responsiveness to interferon (IFN)-alpha and ribavirin therapy (IFN-alpha + RBV).

Design: Retrospective study.

Methods: We carried out a cross-sectional study with 183 IFN-alpha-naive patients on HAART, and 24 healthy controls. We also analyzed 30 out of 183 patients on IFN-alpha + RBV for the duration of 48 weeks.

Results: HIV/HCV coinfected patients had higher levels of sICAM-1 and sVCAM-1 than the healthy control group (P < 0.05). Patients with HCV-genotype 1, advanced fibrosis (F>or=3) or moderate to severe activity grade (A>or=2) had the highest values of sICAM-1 and sVCAM-1. When we carried out a multivariate analysis, we found a significant positive relationship between both HCV-genotype 1 and advanced fibrosis (F>or=3) with sICAM-1 (R = 0.549; P < 0.001); and a significant positive relationship between HCV-genotype 1 and advanced fibrosis (F>or=3) with sVCAM-1 (R = 0.624; P < 0.001). We also found a positive relationship of sICAM-1 or sVCAM-1 levels with transaminases and alkaline phosphatase circulation levels (P < 0.05). Nonresponder patients had higher sICAM-1 and sVCAM-1 serum levels, and patients with sustained virologic response had significantly lower levels of sICAM-1 (P = 0.001) and sVCAM-1 (P = 0.019).

Conclusion: HIV and HCV coinfection induces alterations in sICAM-1 and sVCAM-1 serum levels, which were higher in patients with HCV-genotype 1 and advanced stage of HCV infection. However, response to IFN-alpha + RBV may reduce these cardiovascular risk markers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antiretroviral Therapy, Highly Active / adverse effects*
  • Biomarkers / blood
  • Cardiovascular Diseases / chemically induced*
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / virology
  • Cross-Sectional Studies
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • Hepacivirus / physiology*
  • Hepatitis C / drug therapy*
  • Hepatitis C / immunology
  • Hepatitis C / virology
  • Humans
  • Intercellular Adhesion Molecule-1 / blood*
  • Male
  • Retrospective Studies
  • Vascular Cell Adhesion Molecule-1 / blood*
  • Viral Load

Substances

  • Biomarkers
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1