Abstract
Aptamer functionalized addressable SWNT-film arrays between cantilever electrodes were successfully developed for biosensor applications. Dielectrophoretically aligned SWNT suspended films made possible highly specific and rapid detection of target proteins with a large binding surface area. Thrombin aptamer immobilized SWNT-film FET biosensor resulted in a real-time, label-free, and electrical detection of thrombin molecules down to a concentration of ca. 7 pM with a step-wise rapid response time of several seconds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aptamers, Nucleotide / chemistry*
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Aptamers, Nucleotide / metabolism
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Biosensing Techniques / methods*
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Electromagnetic Fields
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Electrophoresis / methods*
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Microscopy, Electron, Scanning
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Nanotubes / chemistry*
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Protein Binding
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Proteins / chemistry*
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Proteins / metabolism
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Vascular Endothelial Growth Factor A / chemistry
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Vascular Endothelial Growth Factor A / metabolism
Substances
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Aptamers, Nucleotide
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Proteins
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Vascular Endothelial Growth Factor A
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thrombin aptamer