Serotypes and susceptibilities of paediatric clinical isolates of Streptococcus pneumoniae in Crete, Greece, before and after the heptavalent pneumococcal conjugate vaccine

Eur J Clin Microbiol Infect Dis. 2010 Nov;29(11):1449-51. doi: 10.1007/s10096-010-1005-0. Epub 2010 Jul 10.

Abstract

All Streptococcus pneumoniae strains isolated from paediatric clinical samples at Heraklion University General Hospital in the 10-year period 2000-2009 were tested for serotype and susceptibility to antimicrobials. Among a total of 258 strains, 159 were isolated in the 5-year period 2000-2004, before the introduction of the heptavalent pneumococcal conjugate vaccine (PCV7), and 99 in the post-PCV7 5-year period 2005-2009. The prevalence of PCV7-included serotypes decreased in the post-PCV7 period (p = 0.0002), but an increase was observed for serotypes 7F (p = 0.002) and 19A (p = 0.004). Pan-susceptibility rates and susceptibility to cotrimoxazole increased in the post-PCV7 period (p = 0.01 and p = 0.008, respectively), but serotype 19A emerged as a contributor to multi-resistance (p = 0.007). PCV7 was followed by decreased S. pneumoniae resistance and prevalence of vaccine-related serotypes but increased prevalence of serotypes 7F and 19A. Continuing surveillance is required after the recent introduction of PCV10 and PCV13.

Publication types

  • Historical Article

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / pharmacology*
  • Child
  • Child, Preschool
  • Chloramphenicol / pharmacology
  • Clindamycin / pharmacology
  • Greece
  • Heptavalent Pneumococcal Conjugate Vaccine
  • History, 21st Century
  • Humans
  • Immunization Programs
  • Macrolides / pharmacology
  • Microbial Sensitivity Tests
  • Pneumococcal Infections / immunology
  • Pneumococcal Infections / microbiology*
  • Pneumococcal Infections / prevention & control
  • Pneumococcal Vaccines*
  • Quinolones / pharmacology
  • Serotyping
  • Streptococcus pneumoniae / classification*
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / immunology
  • Streptococcus pneumoniae / isolation & purification
  • Tetracycline / pharmacology
  • Trimethoprim, Sulfamethoxazole Drug Combination / pharmacology
  • Vaccines, Conjugate / immunology
  • Vancomycin / pharmacology
  • beta-Lactams / pharmacology

Substances

  • Anti-Bacterial Agents
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Macrolides
  • Pneumococcal Vaccines
  • Quinolones
  • Vaccines, Conjugate
  • beta-Lactams
  • Clindamycin
  • Chloramphenicol
  • Vancomycin
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Tetracycline