Abstract
An 11-year-old girl with metastatic neuroblastoma developed recurrent bacteremia during sustained neutropenia after autologous peripheral blood transplantation. All febrile episodes of bacteremia were caused by single Delftia acidovorans strain revealed by ERIC-PCR. This strain became resistant to broad-spectrum penicillins and cephalosporins through antibiotic treatments. Removal of the indwelling vascular catheter resulted in resolution of the infection. So far as we know, this is the first report of vascular catheter-related D. acidovorans bacteremia in Japan.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Bacteremia / drug therapy
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Bacteremia / microbiology*
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Catheter-Related Infections / drug therapy
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Catheter-Related Infections / microbiology*
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Catheters, Indwelling / microbiology*
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Child
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DNA, Bacterial / analysis
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Delftia acidovorans / drug effects*
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Delftia acidovorans / genetics
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Delftia acidovorans / isolation & purification
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Drug Resistance, Bacterial
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Female
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Gram-Negative Bacterial Infections / drug therapy
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Gram-Negative Bacterial Infections / microbiology*
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Humans
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Japan
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Microbial Sensitivity Tests
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Neuroblastoma / microbiology*
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Opportunistic Infections / drug therapy
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Opportunistic Infections / microbiology
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Peripheral Blood Stem Cell Transplantation
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Polymerase Chain Reaction
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RNA, Ribosomal, 16S / analysis
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beta-Lactams / pharmacology
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beta-Lactams / therapeutic use
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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RNA, Ribosomal, 16S
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beta-Lactams