Size of basal ganglia in suicide attempters, and its association with temperament and serotonin transporter density

Fredrik Johannes Vang; Erik Ryding; Lil Träskman-Bendz; Danielle van Westen; Mats Bertil Lindström

doi:10.1016/j.pscychresns.2010.05.007

Size of basal ganglia in suicide attempters, and its association with temperament and serotonin transporter density

Psychiatry Res. 2010 Aug 30;183(2):177-9. doi: 10.1016/j.pscychresns.2010.05.007. Epub 2010 Jul 13.

Authors

Fredrik Johannes Vang¹, Erik Ryding, Lil Träskman-Bendz, Danielle van Westen, Mats Bertil Lindström

Affiliation

¹ Psychiatry, Department of Clinical Sciences, Lund University, Lund University, SE-221 85 Lund, Sweden. [email protected]

PMID: 20630716
DOI: 10.1016/j.pscychresns.2010.05.007

Abstract

Magnetic resonance imaging was used to compare subcortical volumes of seven suicide attempters with those of six healthy controls. Suicide attempters had 10% smaller right caudate nucleus and 19% bilaterally smaller globus pallidus. In suicide attempters, volumes of the globus pallidus correlated negatively with previously reported measures of solidity (non-impulsive temperament) and serotonin transporter binding potential.

MeSH terms

Basal Ganglia / diagnostic imaging
Basal Ganglia / pathology*
Cocaine / analogs & derivatives
Female
Functional Laterality
Humans
Magnetic Resonance Imaging / methods
Male
Personality Inventory
Protein Binding
Radionuclide Imaging
Serotonin Plasma Membrane Transport Proteins / metabolism*
Suicide, Attempted* / psychology
Temperament*

Substances

Serotonin Plasma Membrane Transport Proteins
2beta-carbomethoxy-3beta-(4-iodophenyl)tropane
Cocaine