Anti-allergic drugs and the Annexin-A1 system

Pharmacol Rep. 2010 May-Jun;62(3):511-7. doi: 10.1016/s1734-1140(10)70307-8.

Abstract

This paper, which was presented at the 17th JMRC 'John Robert Vane Memorial' Symposium, describes some recent work from the authors' laboratory that provides a tentative explanation for the anti-inflammatory effects produced by the cromoglycate-like anti-allergic drugs. Some of the implications of this finding are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Annexin A1 / metabolism*
  • Anti-Allergic Agents / metabolism
  • Anti-Allergic Agents / pharmacology*
  • Cromolyn Sodium / metabolism
  • Cromolyn Sodium / pharmacology
  • Humans
  • Inflammation / metabolism
  • Mast Cells / metabolism
  • U937 Cells

Substances

  • Annexin A1
  • Anti-Allergic Agents
  • Cromolyn Sodium