JAK/STAT signaling in renal diseases

Kidney Int. 2010 Aug;78(3):231-4. doi: 10.1038/ki.2010.158.

Abstract

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a pleiotropic cascade essential to cytokine and growth hormone receptor signaling. Signaling through the JAK/STAT pathway is important for the kidney's response to injury in disease. Pang et al. confirm that activation of STAT3 mediates renal fibrosis in the unilateral ureteral obstruction experimental model.

Publication types

  • Comment
  • Editorial

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental / metabolism
  • Diabetes Mellitus, Experimental / pathology
  • Diabetic Nephropathies / metabolism*
  • Fibrosis / metabolism
  • Fibrosis / pathology
  • Humans
  • Janus Kinases / metabolism*
  • Kidney / pathology
  • Kidney Diseases* / metabolism
  • Kidney Diseases* / pathology
  • Mice
  • Mice, Transgenic
  • Signal Transduction / physiology*
  • Ureteral Obstruction / complications*

Substances

  • Janus Kinases