Identification of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase B

Angew Chem Int Ed Engl. 2010 Aug 9;49(34):5902-5. doi: 10.1002/anie.201002138.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / antagonists & inhibitors*
  • Bacterial Proteins / metabolism
  • Circular Dichroism
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Indoles / chemistry*
  • Indoles / pharmacology
  • Mycobacterium tuberculosis / enzymology*
  • Protein Tyrosine Phosphatases / antagonists & inhibitors*
  • Protein Tyrosine Phosphatases / metabolism
  • Spiro Compounds / chemistry
  • Thiazolidines / chemistry

Substances

  • Bacterial Proteins
  • Enzyme Inhibitors
  • Indoles
  • Spiro Compounds
  • Thiazolidines
  • indolin-2-one
  • Protein Tyrosine Phosphatases