EBV-related cytotoxicity of Fc receptor negative T lymphocytes separated from the blood of infectious mononucleosis patients

Cancer Lett. 1978 Apr;4(4):185-9. doi: 10.1016/s0304-3835(78)94347-1.

Abstract

Epstein-Barr virus (EBV) related specific killing was demonstrated previously in the T cell enriched subpopulations of blood lymphocytes of IM patients. In the present work we demonstrate that the cytotoxic cells belong to the Fc negative T subset. T cells in the blood of IM patients can be divided in 2 categories, 1 Fc positive with non discriminative cytotoxicity and the other, Fc negative with selective cytotoxicity against EBV genome carrying lymphoblastoid cell lines.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Cytotoxicity, Immunologic*
  • Herpesvirus 4, Human / immunology*
  • Humans
  • Immunity, Innate
  • Immunoglobulin Fc Fragments*
  • In Vitro Techniques
  • Infectious Mononucleosis / immunology*
  • T-Lymphocytes / immunology*

Substances

  • Immunoglobulin Fc Fragments