Abstract
Neurological complications of therapeutic procedures for brain tumors are increasingly being recognized. These encompass the classic types of central and peripheral neurotoxicity, such as radiotherapy-induced leukoencephalopathy and platinum-induced neuropathy. However, the advent of novel protocols and targeted therapeutics has expanded the spectrum of neurological complications. A problem of considerable importance is pseudoprogression after radiochemotherapy with temozolomide. Among the new targeted drugs complications of therapy with bevacizumab are the subject of intense discussion. In this review article the neurotoxic potential of intrathecal chemotherapy, kinase inhibitors, immunological strategies and local therapies are summarized. Knowledge about neurological complications of brain tumor therapy procedures is important for risk assessment and patient information.
MeSH terms
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Angiogenesis Inhibitors / administration & dosage
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Angiogenesis Inhibitors / toxicity
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Monoclonal / toxicity
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Antibodies, Monoclonal, Humanized
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Antimetabolites, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic / toxicity
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / adverse effects*
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Antineoplastic Agents / therapeutic use
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Antineoplastic Agents / toxicity*
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Bevacizumab
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Brain / drug effects*
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Brain / radiation effects*
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Brain Damage, Chronic / chemically induced*
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Brain Damage, Chronic / diagnosis*
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Brain Neoplasms / drug therapy*
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Brain Neoplasms / mortality
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Brain Neoplasms / radiotherapy*
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Combined Modality Therapy
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Cranial Irradiation / adverse effects*
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Disease-Free Survival
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Humans
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Injections, Spinal
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Leukoencephalopathies / diagnosis
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Organoplatinum Compounds / administration & dosage
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Organoplatinum Compounds / toxicity
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Peripheral Nerves / drug effects
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Peripheral Nerves / radiation effects
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Protein Kinase Inhibitors / administration & dosage
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Protein Kinase Inhibitors / toxicity
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Radiation Injuries / diagnosis*
Substances
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Angiogenesis Inhibitors
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Antimetabolites, Antineoplastic
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Antineoplastic Agents
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Organoplatinum Compounds
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Protein Kinase Inhibitors
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Bevacizumab