Purpose of review: Bone has always been considered a target organ for neoplastic disorder. This review analyzed the close interaction between bone microenvironment and paraproteinemias.
Recent findings: Paraproteinemias are a group of disorders characterized by the presence of a monoclonal protein measured in the blood or urine. Paraproteinemias include nonmalignant B cell disorders such as monoclonal gammopathy of undetermined significance and malignant diseases as multiple myeloma. All these conditions are characterized by increased risk of osteoporosis/osteopenia, and in the setting of multiple myeloma can manifest with osteolytic pattern.
Summary: This review focuses on the biological aspects of paraproteinemia and bone disease, and indicates possible new therapeutic interventions.