The human kininogen gene (KNG) mapped to chromosome 3q26-qter by analysis of somatic cell hybrids using the polymerase chain reaction

Hum Genet. 1991 Jun;87(2):189-92. doi: 10.1007/BF00204179.

Abstract

Kinins, peptide products of kininogens, may be involved in hypertensive and diabetic diseases, and inflammatory disorders. The human kininogen gene (KNG) has been mapped to chromosome 3, using a panel of human-hamster somatic cell hybrids by polymerase chain reaction of hybrid DNA with gene-specific primers. KNG was further assigned to 3q26-3qter, using DNA from a second panel of chromosome 3 deletion mapping cell hybrids.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 3*
  • Cricetinae
  • Electrophoresis, Agar Gel
  • Humans
  • Hybrid Cells
  • In Vitro Techniques
  • Kininogens / genetics*
  • Molecular Sequence Data
  • Polymerase Chain Reaction

Substances

  • Kininogens