The advent of magnifying chromoendoscopy has enabled endoscopists to observe the mucosal structures in great detail for precise diagnosis; the pit patterns, irregular vascular patterns with narrow band imaging(NBI), and intra-epithelial papillary capillary loop (IPCL) pattern. The achievement of high resolution images has also improved accuracy of diagnosis for neoplasm in gastroenterology. Endocytoscopy is developed from magnifying chromoendoscopy, and is now under clinical investigation for use. Many of early gastrointestinal carcinoma has been treated endoscopically, and ESD (endoscopic submucosal dissection) technique, resection of the neoplasm en bloc, has disseminated recent years. The indication for ESD will be broadened in the near future, and the precise diagnosis for the neoplasm is essential, not to loose the interest of patients.