Novel use of insulin in continuous-instillation negative pressure wound therapy as "wound chemotherapy"

J Diabetes Sci Technol. 2010 Jul 1;4(4):820-4. doi: 10.1177/193229681000400408.

Abstract

Negative pressure wound therapy (NPWT) is frequently employed in the treatment of complex wounds. A variety of wound chemotherapeutic agents such as insulin, which acts as a growth factor, may prove helpful in treatment as well. We present a case report in which insulin was used as a chemotherapeutic agent in continuous-instillation NPWT. To our knowledge, this is the first report in the literature describing this method of delivery.

Publication types

  • Case Reports
  • Historical Article
  • Review

MeSH terms

  • Administration, Topical
  • Aged
  • Diabetes Complications / drug therapy
  • Diabetes Complications / pathology
  • Diabetic Foot / drug therapy
  • Diabetic Foot / pathology
  • History, 20th Century
  • Humans
  • Hypoglycemic Agents / administration & dosage
  • Hypoglycemic Agents / history
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / administration & dosage
  • Insulin / history
  • Insulin / therapeutic use*
  • Male
  • Negative-Pressure Wound Therapy / methods*
  • Wound Healing / drug effects*
  • Wounds and Injuries / drug therapy*
  • Wounds and Injuries / pathology

Substances

  • Hypoglycemic Agents
  • Insulin