[Thrombotic microangiopathy following kidney transplantation revealing factors H and I deficiencies]

J-B Fraison; V Pernin; C Alméras; F Vetromile; V Frémeaux-Bacchi; G Mourad

doi:10.1016/j.revmed.2010.06.013

[Thrombotic microangiopathy following kidney transplantation revealing factors H and I deficiencies]

Rev Med Interne. 2011 Jun;32(6):e81-3. doi: 10.1016/j.revmed.2010.06.013. Epub 2010 Jul 27.

[Article in French]

Authors

J-B Fraison¹, V Pernin, C Alméras, F Vetromile, V Frémeaux-Bacchi, G Mourad

Affiliation

¹ Service de médecine interne, centre hospitalier de Béziers, 2 rue Valentin-Hauÿ, Béziers, France. [email protected]

PMID: 20667630
DOI: 10.1016/j.revmed.2010.06.013

Abstract

A 52-year-old man with an end stage renal failure of undetermined aetiology was hemodialysed in 2002. He received a cadaveric kidney transplantation in 2004. After an episode of diarrhea, a thrombotic microangiopathy was diagnosed in July 2009 and during this episode, a low C3 serum level was identified. Plasma exchanges were beneficial. Exploration of the low C3 serum level revealed both factor H and factor I deficiencies. We think that the renal failure of undetermined aetiology was probably an unnoticed haemolytic and uremic syndrome which recurred more than five years after transplantation.

Publication types

Case Reports
English Abstract

MeSH terms

Complement Factor H / deficiency*
Complement Factor I / deficiency*
Humans
Kidney Transplantation / adverse effects*
Male
Middle Aged
Thrombotic Microangiopathies / etiology*

Substances

Complement Factor H
Complement Factor I