Relapsing infiltrates after pneumocystis pneumonia in stem cell transplant patients: think about BOOP!

Acta Clin Belg. 2010 May-Jun;65(3):200-1. doi: 10.1179/acb.2010.042.

Abstract

Bronchiolitis Obliterans Organizing Pneumonia (BOOP) can complicate allogeneic haematopoietic stem cell transplantation. It is associated with prior graft-versus-host disease (GVHD) and the case fatality is 21%. In 22%, diagnosis is preceded by tapering the corticosteroids given as a treatment for GVHD. We report a fatal case of BOOP after tapering the corticosteroids that the patient received for a Pneumocystis jirovecii pneumonia after stem cell transplantation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Cryptogenic Organizing Pneumonia / diagnosis*
  • Cryptogenic Organizing Pneumonia / etiology*
  • Cryptogenic Organizing Pneumonia / therapy
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / adverse effects
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Male
  • Methylprednisolone / administration & dosage
  • Methylprednisolone / adverse effects
  • Pneumocystis carinii*
  • Pneumonia, Pneumocystis / complications*
  • Pneumonia, Pneumocystis / drug therapy
  • Pneumonia, Pneumocystis / pathology

Substances

  • Glucocorticoids
  • Methylprednisolone