The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

Thorbald van Hall; Claudia C Oliveira; Simone A Joosten; Tom H M Ottenhoff

doi:10.1016/j.micinf.2010.07.011

The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

Microbes Infect. 2010 Nov;12(12-13):910-8. doi: 10.1016/j.micinf.2010.07.011. Epub 2010 Jul 27.

Authors

Thorbald van Hall¹, Claudia C Oliveira, Simone A Joosten, Tom H M Ottenhoff

Affiliation

¹ Department of Clinical Oncology, Leiden University Medical Center, K1-P, Albinusdreef 2, 2333 ZA Leiden, Netherlands. [email protected]

PMID: 20670688
DOI: 10.1016/j.micinf.2010.07.011

Abstract

The non-polymorphic MHC molecule Qa-1 and its human counterpart HLA-E present monomorphic signal peptides to innate receptors and thereby regulate lymphocyte activity. Under stress, this peptide content is replaced with a surprisingly diverse repertoire of novel peptides that are associated with heat-shock proteins, infectious agents or antigen processing defects.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antigen Presentation*
HLA Antigens / immunology*
HLA-E Antigens
Histocompatibility Antigens Class I / immunology*
Humans
Immunity, Cellular*
Mice
Signal Transduction

Substances

HLA Antigens
Histocompatibility Antigens Class I
Q surface antigens

Grants and funding

09-0776/AICR_/Worldwide Cancer Research/United Kingdom