DNA repair has a new FAN1 club

Lara O'Donnell; Daniel Durocher

doi:10.1016/j.molcel.2010.07.010

DNA repair has a new FAN1 club

Mol Cell. 2010 Jul 30;39(2):167-9. doi: 10.1016/j.molcel.2010.07.010.

Authors

Lara O'Donnell¹, Daniel Durocher

Affiliation

¹ Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.

PMID: 20670886
DOI: 10.1016/j.molcel.2010.07.010

Abstract

In recent issues of Molecular Cell, Cell, and Science, Smogorzewska et al. (2010), MacKay et al. (2010), Kratz et al. (2010), and Liu et al. (2010) identify FAN1 as a nuclease that is recruited to sites of interstrand crosslinks by ubiquitylated FANCD2, where it participates in DNA repair. The identification of FAN1 fills a missing link in interstrand crosslink DNA repair.

Publication types

Comment