Abstract
We report an exceptional case of life-threatening Escherichia coli-induced necrotizing fasciitis. A combined host-pathogen genetic analysis explained the phenotype: the host displayed a susceptibility to intravascular coagulation, and the strain was capable of producing a necrotic toxin (cytotoxic necrotizing factor 1), showing how E. coli can be a dermonecrotic pathogen.
MeSH terms
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Aged, 80 and over
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Bacterial Toxins / biosynthesis
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Escherichia coli / classification
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Escherichia coli / isolation & purification*
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Escherichia coli / pathogenicity*
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Escherichia coli Infections / diagnosis*
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Escherichia coli Infections / microbiology*
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Escherichia coli Proteins / biosynthesis
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Fasciitis, Necrotizing / diagnosis*
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Fasciitis, Necrotizing / microbiology*
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Fasciitis, Necrotizing / pathology
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Histocytochemistry
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Humans
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Leg / microbiology
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Leg / pathology
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Male
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Microscopy
Substances
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Bacterial Toxins
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Escherichia coli Proteins
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cytotoxic necrotizing factor type 1