Abstract
Among the 77 infiltrating breast carcinomas, we found that progesterone receptor (PR) expression was inversely associated with recurrence score (RS, p < .0001). RS is also significantly associated with tubule formation, mitosis, and luminal B subtype. The equation of RS = 17.489 + 2.071 (tubal formation) + 2.926 (mitosis) -2.408 (PR) -1.061 (HER2) + 7.051 (luminal A) + 29.172 (luminal B) predicts RS with an R² of 0.65. In conclusion, PR negativity, luminal B subtype, tubal formation, and mitosis are strongly correlated with a higher RS.
MeSH terms
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism*
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Breast Neoplasms / genetics
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology*
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Female
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Gene Expression Regulation, Neoplastic
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Humans
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Immunohistochemistry
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Middle Aged
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Neoplasm Recurrence, Local
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Prognosis
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Receptor, ErbB-2 / genetics
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Receptor, ErbB-2 / metabolism
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Receptors, Estrogen / genetics
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Receptors, Estrogen / metabolism
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Receptors, Progesterone / genetics
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Receptors, Progesterone / metabolism*
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Retrospective Studies
Substances
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Biomarkers, Tumor
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Receptors, Estrogen
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Receptors, Progesterone
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Receptor, ErbB-2