Neuroscience. A glutamate pathway to faster-acting antidepressants?

Science. 2010 Aug 20;329(5994):913-4. doi: 10.1126/science.1194313.

Authors

John F Cryan¹, Olivia F O'Leary

Affiliation

¹ School of Pharmacy, Department of Pharmacology and Therapeutics, Alimentary Pharmabiotic Centre, University College Cork, College Road, Cork, Ireland. [email protected]

PMID: 20724626
DOI: 10.1126/science.1194313

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Antidepressive Agents / pharmacokinetics*
Drug Synergism
Excitatory Amino Acid Antagonists / pharmacology*
Excitatory Amino Acid Antagonists / therapeutic use
Humans
Intracellular Signaling Peptides and Proteins / antagonists & inhibitors
Intracellular Signaling Peptides and Proteins / metabolism
Ketamine / pharmacology*
Ketamine / therapeutic use
Protein Serine-Threonine Kinases / antagonists & inhibitors
Protein Serine-Threonine Kinases / metabolism
Rats
Sirolimus / pharmacology
Synaptic Transmission / drug effects
TOR Serine-Threonine Kinases

Substances

Antidepressive Agents
Excitatory Amino Acid Antagonists
Intracellular Signaling Peptides and Proteins
Ketamine
MTOR protein, human
Protein Serine-Threonine Kinases
TOR Serine-Threonine Kinases
Sirolimus