An asymptomatic 61-year-old man with BCR-ABL-positive bone marrow following autologous transplantation for multiple myeloma

Am J Hematol. 2010 Dec;85(12):944-6. doi: 10.1002/ajh.21809.

Abstract

A 61-year-old man treated with an autologous transplant for multiple myeloma was incidentally found to have a high level of BCR-ABL fusion gene-positive cells in his bone marrow. We describe the clinical decision-making process that led us to initiate therapy with imatinib, despite the absence of any clinical evidence of chronic myelogenous leukemia or other BCR-ABL associated hematologic malignancy.

Publication types

  • Case Reports

MeSH terms

  • Bone Marrow Transplantation / methods*
  • Bone Marrow*
  • Fusion Proteins, bcr-abl / analysis*
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Male
  • Middle Aged
  • Multiple Myeloma / complications*
  • Multiple Myeloma / diagnosis
  • Multiple Myeloma / therapy
  • Remission Induction / methods
  • Transplantation, Autologous

Substances

  • Fusion Proteins, bcr-abl