Abstract
To develop more potent therapeutic agents with therapeutic efficacy for ischemia/reperfusion (I/R) injury, we linked an antiinflammatory moiety (1,3-dioxane derivative) to the key pharmacophoric moiety of melatonin. We hypothesized that the resulting new indole derivatives might induce a synergistic protection against oxidative damage associated with I/R injury. Our results indicate that one of these indole derivatives (7) manifests potent antiinflammatory antioxidant effects and exerts a protective effect against skeletal muscle injury and associated lung injury following limb I/R in rats.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
-
Anti-Inflammatory Agents, Non-Steroidal / chemistry
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
-
Antioxidants / chemical synthesis*
-
Antioxidants / chemistry
-
Antioxidants / pharmacology
-
Capillary Permeability
-
Free Radical Scavengers / chemical synthesis
-
Free Radical Scavengers / chemistry
-
Free Radical Scavengers / pharmacology
-
Hindlimb / blood supply
-
Indoles / chemical synthesis*
-
Indoles / chemistry
-
Indoles / pharmacology
-
Inflammation / drug therapy
-
Lipid Peroxidation / drug effects
-
Lung Injury / drug therapy
-
Lung Injury / metabolism
-
Lung Injury / pathology
-
Mice
-
Muscle, Skeletal / blood supply
-
Muscle, Skeletal / drug effects
-
Muscle, Skeletal / pathology
-
PC12 Cells
-
Rats
-
Reperfusion Injury / drug therapy*
-
Reperfusion Injury / metabolism
-
Reperfusion Injury / pathology
-
Structure-Activity Relationship
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Antioxidants
-
Free Radical Scavengers
-
Indoles