Mediastinal germ cell tumor with somatic-type malignancy: report of 5 stage I/II cases

Keisuke Asakura; Yotaro Izumi; Tatsuhiko Ikeda; Yoshishige Kimura; Hirohisa Horinouchi; Yuichiro Hayashi; Hiroaki Nomori

doi:10.1016/j.athoracsur.2009.12.081

Mediastinal germ cell tumor with somatic-type malignancy: report of 5 stage I/II cases

Ann Thorac Surg. 2010 Sep;90(3):1014-6. doi: 10.1016/j.athoracsur.2009.12.081.

Authors

Keisuke Asakura¹, Yotaro Izumi, Tatsuhiko Ikeda, Yoshishige Kimura, Hirohisa Horinouchi, Yuichiro Hayashi, Hiroaki Nomori

Affiliation

¹ Division of General Thoracic Surgery, School of Medicine, Keio University, Tokyo, Japan.

PMID: 20732540
DOI: 10.1016/j.athoracsur.2009.12.081

Abstract

Among 15 patients with primary mediastinal nonseminomatous germ cell tumors experienced during the past 12 years, 5 were diagnosed with germ cell tumors with somatic-type malignancy. The pretreatment stages were stage I in 2 patients and stage II in 3. All 5 patients received perioperative chemotherapy plus surgical resection, and 4 remain alive without relapse, with a mean follow-up of 60 months.

MeSH terms

Adult
Combined Modality Therapy
Humans
Male
Mediastinal Neoplasms / pathology*
Mediastinal Neoplasms / therapy*
Middle Aged
Neoplasm Staging
Neoplasms, Germ Cell and Embryonal / pathology*
Neoplasms, Germ Cell and Embryonal / therapy*
Young Adult