Long-term survival of a patient with leptomeningeal involvement by nasopharyngeal carcinoma after treatment with high-dose intravenous methotrexate

Head Neck. 2012 Feb;34(2):296-300. doi: 10.1002/hed.21516. Epub 2010 Aug 24.

Abstract

Background: Nasopharyngeal carcinoma with leptomeningeal involvement is rare and typically has poor prognosis.

Methods and results: We present a case report of a patient with nasopharyngeal carcinoma who was treated with high-dose intravenous methotrexate and remains asymptomatic and without clinical evidence of disease 6 years later.

Conclusions: Systemic high-dose methotrexate should be evaluated in the treatment of advanced nasopharyngeal carcinoma with central nervous involvement.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antimetabolites, Antineoplastic / administration & dosage
  • Cisplatin / administration & dosage
  • Fluorouracil / administration & dosage
  • Humans
  • Infusions, Intravenous
  • Magnetic Resonance Imaging
  • Male
  • Meningeal Carcinomatosis / complications
  • Meningeal Carcinomatosis / drug therapy*
  • Meningeal Carcinomatosis / pathology*
  • Methotrexate / administration & dosage*
  • Nasopharyngeal Neoplasms / diagnosis
  • Nasopharyngeal Neoplasms / drug therapy
  • Nasopharyngeal Neoplasms / pathology*
  • Nasopharyngeal Neoplasms / radiotherapy
  • Neoplasm Invasiveness
  • Radiotherapy Dosage

Substances

  • Antimetabolites, Antineoplastic
  • Cisplatin
  • Fluorouracil
  • Methotrexate