Abstract
Aziridinomitosane ketones 4 and 24 are accessed by internal acyl anion equivalent-lactam cyclization of 29 in a convergent route. The key aziridinolactam 6 is prepared by tin-lithium exchange via the lithiated aziridine 11.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Aziridines / chemistry*
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Catalysis
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Cyclization
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Mitomycins / chemistry*
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Molecular Structure
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Stereoisomerism
Substances
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Aziridines
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Mitomycins
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mitosane
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aziridine