Understanding the impact of the acquired immune deficiency syndrome (AIDS) epidemic is critical for developing appropriate interventions to create supportive environments for orphans and vulnerable children (OVC). Unfortunately, there are very few studies on the psychosocial wellbeing of children orphaned by AIDS in Africa, and even fewer in Tanzania. It has been difficult to make generalizations across studies and to identify and track children suffering from mental health difficulties, given the lack of culturally sensitive, standardized screening scales and diagnostic procedures. As a contribution to filling that gap, the current study demonstrates the applicability of an existing depression screening instrument (CDI) to evaluate both the needs of OVC as well as the effectiveness of interventions designed to support them.