An experimental and computational study on the epimeric contribution to the infrared spectrum of budesonide

H R H Ali; H G M Edwards; J Kendrick; T Munshi; I J Scowen

doi:10.1002/dta.152

An experimental and computational study on the epimeric contribution to the infrared spectrum of budesonide

Drug Test Anal. 2010 Sep;2(9):447-51. doi: 10.1002/dta.152.

Authors

H R H Ali¹, H G M Edwards, J Kendrick, T Munshi, I J Scowen

Affiliation

¹ Department of Pharmaceutical Analytical Chemistry, University of Assiut, Egypt. [email protected]

PMID: 20812265
DOI: 10.1002/dta.152

Abstract

Budesonide is a mixture of 22R and 22S epimers. The epimeric content of budesonide was reported in both British and European pharmacopoeias to be within the range of 60-49/40-51 for R and S epimers, respectively. In this work, contribution of the two epimers to the overall infrared spectrum of budesonide has been investigated by quantum chemical calculations.

MeSH terms

Budesonide / chemistry*
Spectrophotometry, Infrared
Spectrum Analysis, Raman
Stereoisomerism
Vibration
X-Ray Diffraction

Substances

Budesonide