Multiple-bolus dynamic contrast-enhanced MRI in the pancreas during a glucose challenge

J Magn Reson Imaging. 2010 Sep;32(3):622-8. doi: 10.1002/jmri.22281.

Abstract

Purpose: To assess the feasibility of multiple-bolus dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in the pancreas; to optimize the analysis; and to investigate application of the method to a glucose challenge in type 2 diabetes.

Materials and methods: A 4-bolus DCE-MRI protocol was performed on five patients with type 2 diabetes and 11 healthy volunteers during free-breathing. Motion during the dynamic time series was corrected for using a model-driven nonlinear registration. A glucose challenge was administered intravenously between the first and second DCE-MRI acquisition in all patients and in seven of the healthy controls.

Results: Image registration improved the reproducibility of the DCE-MRI model parameters across the repeated bolus-acquisitions in the healthy controls with no glucose challenge (eg, coefficient of variation for K(trans) improved from 38% to 28%). Native tissue T(1) was significantly lower in patients (374 +/- 68 msec) compared with volunteers (519 +/- 41 msec) but there was no significant difference in any of the baseline DCE-MRI parameters. No effect of glucose challenge was observed in either the patients or healthy volunteers.

Conclusion: Multiple bolus DCE-MRI is feasible in the pancreas and is improved by nonlinear image registration but is not sensitive to the effects of an intravenous glucose challenge.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Blood Glucose / analysis
  • Case-Control Studies
  • Contrast Media*
  • Diabetes Mellitus, Type 2 / diagnosis*
  • Female
  • Gadolinium DTPA*
  • Glucose Tolerance Test
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Pancreas / anatomy & histology*
  • Pulse Therapy, Drug
  • Reproducibility of Results
  • Sensitivity and Specificity

Substances

  • Blood Glucose
  • Contrast Media
  • gadodiamide
  • Gadolinium DTPA