Abstract
Aggressive natural killer cell leukemia (ANKL) is a highly aggressive lymphoproliferative disease. An appropriate therapeutic strategy for ANKL remains to be established, but a few case reports have suggested that allogeneic hematopoietic stem cell transplantation (allo-HCT) can be curative. Here, we report a young woman with ANKL showing central nervous system (CNS) invasion, who has been in complete remission for more than a year after allo-HCT following two courses of intravenous chemotherapy and several rounds of intrathecal chemotherapy. Intensive remission induction chemotherapy followed by conventional myeloablative allo-HCT is a promising approach for long-term remission in cases of this aggressive malignancy.
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Asparaginase / administration & dosage
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Brain / pathology
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Combined Modality Therapy
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Cyclophosphamide / administration & dosage
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Cytarabine / administration & dosage
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Doxorubicin / administration & dosage
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Epstein-Barr Virus Infections / virology
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Etoposide / administration & dosage
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Female
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Herpesvirus 4, Human / isolation & purification
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Humans
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Ifosfamide / administration & dosage
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Injections, Spinal
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Leukemia, Large Granular Lymphocytic / drug therapy
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Leukemia, Large Granular Lymphocytic / surgery*
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Leukemia, Large Granular Lymphocytic / virology
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Leukemic Infiltration
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Methotrexate / administration & dosage
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Myeloablative Agonists / therapeutic use
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Peripheral Blood Stem Cell Transplantation*
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Prednisone / administration & dosage
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Radiography
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Remission Induction
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Subarachnoid Hemorrhage / diagnostic imaging
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Subarachnoid Hemorrhage / etiology
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Transplantation Conditioning
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Transplantation, Homologous
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Vincristine / administration & dosage
Substances
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Myeloablative Agonists
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Cytarabine
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Vincristine
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Etoposide
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Doxorubicin
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Cyclophosphamide
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Asparaginase
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Ifosfamide
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Prednisone
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Methotrexate