Lung transplantation for severe antineutrophilic cytoplasmic antibody-associated vasculitis

Transplant Proc. 2010 Sep;42(7):2707-10. doi: 10.1016/j.transproceed.2010.04.053.

Abstract

Antineutrophil cytoplasmic antibody-associated vasculitis is a life-threatening disorder for which medical therapy has greatly improved survival. However, there is still significant mortality associated with antineutrophil cytoplasmic antibody-associated vasculitis. Little data exists on the utility of lung transplantation for patients, especially with an acute and severe form of this disease. Herein, we report successful lung transplantation for a patient with life-threatening pulmonary hemorrhage and respiratory failure as a consequence of this pulmonary renal syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antibodies, Antineutrophil Cytoplasmic / blood
  • Antibodies, Antinuclear / immunology*
  • Cyclophosphamide
  • Cytoplasm / immunology
  • Glomerulonephritis / etiology*
  • Hemoptysis
  • Hemorrhage / etiology
  • Humans
  • Lung Transplantation / immunology
  • Lung Transplantation / physiology*
  • Male
  • Plasmapheresis
  • Renal Dialysis / methods
  • Treatment Outcome
  • Vasculitis / immunology
  • Vasculitis / surgery*

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Antibodies, Antinuclear
  • Cyclophosphamide