Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation

Carbohydr Res. 2010 Oct 13;345(15):2277-81. doi: 10.1016/j.carres.2010.07.040. Epub 2010 Aug 2.

Abstract

The synthesis of glycosylated Fmoc amino acids by reaction of mono- and disaccharide peracetates with Fmoc amino acids having free carboxyl groups was rapidly promoted by Lewis acids (SnCl(4), BF(3)·Et(2)O) under microwave irradiation. The products are useful building blocks for the synthesis of glycopeptides.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acids / chemical synthesis*
  • Amino Acids / chemistry
  • Fluorenes / chemical synthesis*
  • Fluorenes / chemistry
  • Glycosylation
  • Magnetic Resonance Spectroscopy
  • Microwaves*
  • Molecular Structure

Substances

  • Amino Acids
  • Fluorenes
  • N(alpha)-fluorenylmethyloxycarbonylamino acids