Application of click-click chemistry to the synthesis of new multivalent RGD conjugates

Org Biomol Chem. 2010 Nov 21;8(22):5133-8. doi: 10.1039/c0ob00070a. Epub 2010 Sep 9.

Abstract

New multivalent RGD-containing macromolecules were designed by exploiting two orthogonal chemoselective ligations. They were next applied to a competitive cell adhesion assay and used for the non invasive optical imaging of tumour in small animals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Assay
  • Cell Adhesion / drug effects
  • Cell Line
  • Chemistry, Organic / methods*
  • Chromatography, High Pressure Liquid
  • Humans
  • Mice
  • Molecular Sequence Data
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / chemistry

Substances

  • Oligopeptides
  • arginyl-glycyl-aspartic acid