Oestrogen downregulates BACE protein in human cell culture: what does this teach us about Alzheimer's disease?

Neurodegener Dis. 2011;8(3):153-4. doi: 10.1159/000320087. Epub 2010 Sep 14.

Authors

Hans-Gert Bernstein¹, Uwe Lendeckel, Johann Steiner, Bernhard Bogerts

Affiliation

¹ Department of Psychiatry, University of Magdeburg, Magdeburg, Germany. [email protected]

PMID: 20838033
DOI: 10.1159/000320087

No abstract available

Publication types

Comment

MeSH terms

Alzheimer Disease / metabolism*
Alzheimer Disease / physiopathology
Amyloid Precursor Protein Secretases / genetics
Amyloid Precursor Protein Secretases / metabolism*
Aspartic Acid Endopeptidases / genetics
Aspartic Acid Endopeptidases / metabolism*
Cells, Cultured
Down-Regulation / drug effects*
Down-Regulation / physiology
Estrogens / pharmacology*
Humans
Neuroglia / cytology
Neuroglia / drug effects
Neuroglia / metabolism*
Neurons / cytology
Neurons / drug effects
Neurons / metabolism*

Substances

Estrogens
Amyloid Precursor Protein Secretases
Aspartic Acid Endopeptidases
BACE1 protein, human