Th17 cells and transplant acceptance

Transplantation. 2010 Nov 15;90(9):945-8. doi: 10.1097/TP.0b013e3181f5c3de.

Abstract

The discovery of Th17 cells has revealed a novel pathway of T-cell maturation. As with Th1 and Th2 lineages, Th17 cells promote graft pathology. However, a growing body of evidence indicates that Th17 cells may exhibit resistance to current methods of immunosuppression. Identification of this lineage provides an additional and challenging target for promoting graft acceptance.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Graft Rejection / immunology
  • Graft Rejection / pathology
  • Humans
  • Inflammation / immunology
  • Liver Transplantation / adverse effects
  • Liver Transplantation / immunology
  • Liver Transplantation / pathology
  • T-Lymphocytes, Regulatory / immunology
  • Th1 Cells / immunology*
  • Th2 Cells / immunology*
  • Transplantation Immunology*