Abstract
Two new eudesmane-type sesquiterpene lactones were isolated from the roots of Inula racemosa and their structures were elucidated as 3β-hydroxy-11α,13-dihydroalantolactone (1) and 11α-hydroxy-eudesm-5-en-8β,12-olide (2). Their cytotoxic activities against five human cancer cell lines had been tested and compound 2 exhibited weak cytotoxic activity against BEL-7402 and HCT-8 cell lines. The anti-inflammatory activities were also tested, but neither of them showed any activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cellulases / antagonists & inhibitors
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Humans
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Inhibitory Concentration 50
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Inula / chemistry*
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Molecular Structure
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Neutrophils / drug effects
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Rats
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Sesquiterpenes, Eudesmane / chemistry
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Sesquiterpenes, Eudesmane / isolation & purification*
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Sesquiterpenes, Eudesmane / pharmacology
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Stereoisomerism
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Tibet
Substances
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11-hydroxy-eudesm-5-en-8beta,12-olide
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3beta-hydroxy-11,13-dihydroalantolactone
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Anti-Inflammatory Agents
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Antineoplastic Agents, Phytogenic
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Sesquiterpenes, Eudesmane
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Cellulases