Birth defects after assisted reproductive technologies in China: analysis of 15,405 offspring in seven centers (2004 to 2008)

Junhao Yan; Guoning Huang; Yingpu Sun; Xiaoming Zhao; Shiling Chen; Shuhua Zou; Cuifang Hao; Song Quan; Zi-Jiang Chen

doi:10.1016/j.fertnstert.2010.08.024

Birth defects after assisted reproductive technologies in China: analysis of 15,405 offspring in seven centers (2004 to 2008)

Fertil Steril. 2011 Jan;95(1):458-60. doi: 10.1016/j.fertnstert.2010.08.024. Epub 2010 Sep 20.

Authors

Junhao Yan¹, Guoning Huang, Yingpu Sun, Xiaoming Zhao, Shiling Chen, Shuhua Zou, Cuifang Hao, Song Quan, Zi-Jiang Chen

Affiliation

¹ Center for Reproductive Medicine, Shandong University, Jinan, People's Republic of China.

PMID: 20850722
DOI: 10.1016/j.fertnstert.2010.08.024

Abstract

This first large-scale report of birth defects in 15,405 offspring conceived by assisted reproductive technologies in China found infants born after IVF alone to have a birth defect frequency comparable to that in the general Chinese population; rates were nonsignificantly higher in infants conceived with use of intracytoplasmic sperm injection compared with those conceived after IVF alone.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

China / epidemiology
Congenital Abnormalities / epidemiology*
Female
Fertilization in Vitro / adverse effects
Fertilization in Vitro / statistics & numerical data
Humans
Infant, Newborn
Insemination, Artificial, Homologous / adverse effects
Insemination, Artificial, Homologous / statistics & numerical data
Pregnancy
Pregnancy Outcome / epidemiology*
Reproductive Techniques, Assisted / adverse effects*
Reproductive Techniques, Assisted / statistics & numerical data*
Sperm Injections, Intracytoplasmic / adverse effects
Sperm Injections, Intracytoplasmic / statistics & numerical data