The vitamin E-binding protein afamin is altered significantly in the peritoneal fluid of women with endometriosis

Fertil Steril. 2010 Dec;94(7):2923-6. doi: 10.1016/j.fertnstert.2010.05.008. Epub 2010 Jun 17.

Abstract

The objective of this case-control study of 242 reproductive-age women was to determine the concentration of afamin in the serum and peritoneal fluid of women with and without endometriosis and to test afamin as a diagnostic marker of endometriosis. Afamin levels were altered significantly in the peritoneal fluid of women with endometriosis compared with disease-free controls, correlated with vitamin E levels, and are consistent with increased oxidative stress in the peritoneal cavity of women with endometriosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Ascitic Fluid / chemistry
  • Ascitic Fluid / metabolism*
  • Ascitic Fluid / pathology
  • Carrier Proteins / analysis
  • Carrier Proteins / blood
  • Carrier Proteins / metabolism*
  • Case-Control Studies
  • Endometriosis / blood
  • Endometriosis / metabolism*
  • Endometriosis / pathology
  • Female
  • Glycoproteins / analysis
  • Glycoproteins / blood
  • Glycoproteins / metabolism*
  • Humans
  • Middle Aged
  • Osmolar Concentration
  • Oxidative Stress / physiology
  • Peritoneal Diseases / blood
  • Peritoneal Diseases / metabolism*
  • Peritoneal Diseases / pathology
  • Serum Albumin / analysis
  • Serum Albumin / metabolism*
  • Serum Albumin, Human
  • Vitamin E / blood
  • Vitamin E / metabolism
  • Young Adult

Substances

  • AFM protein, human
  • Carrier Proteins
  • Glycoproteins
  • Serum Albumin
  • Vitamin E
  • Serum Albumin, Human