Abstract
Estradiol enhanced stromal cell-derived factor 1 (SDF-1/CXCL12) production levels in human endometrial stromal cells (ESCs) in a time- and dose-dependent manner that could be completely abolished by ICI 182,780 (estrogen receptor antagonist) and medroxyprogesterone acetate. Although SDF-1 was undetectable in the Ishikawa human endometrial epithelial cell line, its receptor (CXCR4) messenger RNA levels in Ishikawa cells were much higher than those in ESCs, and furthermore SDF-1 induced the proliferation of Ishikawa cells; SDF-1 secreted from ESCs may play a role in endometrial epithelial cell growth in the paracrine system.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
MeSH terms
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Adult
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Cell Communication / drug effects
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Cell Communication / physiology
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Cell Division / drug effects
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Cell Division / physiology
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Chemokine CXCL12 / metabolism*
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Endometrium / cytology*
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Epithelial Cells / cytology
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Epithelial Cells / drug effects
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Epithelial Cells / metabolism*
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Estradiol / analogs & derivatives
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Estradiol / pharmacology
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Estrogen Antagonists / pharmacology
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Estrogens / metabolism*
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Estrogens / pharmacology
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Female
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Fulvestrant
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Humans
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In Vitro Techniques
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Middle Aged
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Paracrine Communication / drug effects
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Paracrine Communication / physiology
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Stromal Cells / cytology
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Stromal Cells / drug effects
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Stromal Cells / metabolism*
Substances
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CXCL12 protein, human
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Chemokine CXCL12
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Estrogen Antagonists
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Estrogens
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Fulvestrant
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Estradiol