Abstract
Eleven advanced cancer patients affected by malignant bowel obstruction (MBO) were treated at home with a combination of octreotide, metoclopramide, morphine, and dexamethasone. In all patients, we observed a prompt control of gastrointestinal symptoms and recovery of bowel movements within 1-5 days. Based on our results, a combination of drugs with different mechanisms of action allows an effective and safe treatment for MBO at home. Further studies with larger number of patients are warranted to confirm these preliminary data.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Analgesics, Opioid / therapeutic use
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Antiemetics / therapeutic use
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Dexamethasone / therapeutic use
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Drug Therapy, Combination
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Female
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Gastrointestinal Agents / therapeutic use
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Home Care Services, Hospital-Based / organization & administration*
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Humans
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Intestinal Obstruction / drug therapy*
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Intestinal Obstruction / etiology
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Male
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Metoclopramide / therapeutic use
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Middle Aged
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Morphine / therapeutic use
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Neoplasms / complications*
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Octreotide / therapeutic use
Substances
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Analgesics, Opioid
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Antiemetics
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Gastrointestinal Agents
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Morphine
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Dexamethasone
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Metoclopramide
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Octreotide