Prasugrel as alternative treatment strategy in a case with a hypersensitivity reaction to clopidogrel

Jochem W van Werkum; Thijs L Braber; Peter W H M Verheggen; Simone M Van Der Have-Roeffel

doi:10.3109/09537104.2010.514627

Prasugrel as alternative treatment strategy in a case with a hypersensitivity reaction to clopidogrel

Platelets. 2011;22(1):77-8. doi: 10.3109/09537104.2010.514627. Epub 2010 Sep 27.

Authors

Jochem W van Werkum¹, Thijs L Braber, Peter W H M Verheggen, Simone M Van Der Have-Roeffel

Affiliation

¹ Meander Medical Center, Department of Cardiology, Amersfoort, The Netherlands. [email protected]

PMID: 20873964
DOI: 10.3109/09537104.2010.514627

Abstract

We report a case with a hypersensitivity reaction to clopidogrel that resolved after clopidogrel discontinuation and recurred on rechallenge. The reaction included fever, tachycardia, rash and mild angioedema. As an alternative to clopidogrel, the more potent thienopyridine prasugrel was administered without any signs of an allergic reaction in the hours, days and weeks following administration.

Publication types

Case Reports

MeSH terms

Aged
Angioedema
Clopidogrel
Drug Hypersensitivity / physiopathology
Drug Hypersensitivity / prevention & control*
Exanthema
Fever
Humans
Male
Piperazines / administration & dosage
Piperazines / therapeutic use*
Prasugrel Hydrochloride
Purinergic P2Y Receptor Antagonists / administration & dosage
Purinergic P2Y Receptor Antagonists / adverse effects*
Tachycardia
Thiophenes / administration & dosage
Thiophenes / therapeutic use*
Thrombosis / prevention & control
Ticlopidine / administration & dosage
Ticlopidine / adverse effects
Ticlopidine / analogs & derivatives*

Substances

Piperazines
Purinergic P2Y Receptor Antagonists
Thiophenes
Clopidogrel
Prasugrel Hydrochloride
Ticlopidine