Endocannabinoids rein in pain outside the brain

David M Lovinger

doi:10.1038/nn1010-1155

Endocannabinoids rein in pain outside the brain

Nat Neurosci. 2010 Oct;13(10):1155-6. doi: 10.1038/nn1010-1155.

Author

David M Lovinger¹

Affiliation

¹ Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA. [email protected]

Abstract

Enhancers of endocannabinoid signaling are potential analgesics, but they cause unacceptable psychiatric side effects. A new study reports an inhibitor of endocannabinoid breakdown that has analgesic activity and cannot enter the CNS.

Publication types

Comment

MeSH terms

Animals
Brain / drug effects
Brain / metabolism
Cannabinoid Receptor Modulators / metabolism*
Cannabinoid Receptor Modulators / therapeutic use*
Endocannabinoids*
Pain / drug therapy*
Pain / metabolism*
Peripheral Nervous System / drug effects*
Peripheral Nervous System / metabolism

Substances

Cannabinoid Receptor Modulators
Endocannabinoids