Abstract
We present the synthesis of trastuzumab-functionalized pegylated iron oxide nanoparticles and provide an FTIR-based approach to gain a direct evidence of the actual conservation of the native structure of conjugated antibody. Their target-selectivity to specific cancer cell receptors has been also assessed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies / chemistry*
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Antibodies, Monoclonal / chemistry
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Antibodies, Monoclonal, Humanized
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Aspartic Acid / analogs & derivatives
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Aspartic Acid / chemistry
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Cell Line, Tumor
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Ferric Compounds / chemistry
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Fluorescein-5-isothiocyanate / chemistry
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Humans
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Immunoconjugates / chemistry
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Immunoprecipitation
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Magnetics
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Metal Nanoparticles / chemistry*
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Microscopy, Confocal
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Morpholines / chemistry
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Spectroscopy, Fourier Transform Infrared
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Trastuzumab
Substances
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Antibodies
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Ferric Compounds
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Immunoconjugates
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Morpholines
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poly (3-morpholinopropyl) aspartamide
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ferric oxide
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Aspartic Acid
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Fluorescein-5-isothiocyanate
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Trastuzumab