Abstract
The excitatory actions on the unit activities of locus coeruleus induced by excitatory amino acids were studied. Quinolinic acid 10 nmol and N-methyl-D-aspartate (NMDA) 4 nmol icv markedly increased unit discharge of locus coeruleus neurons. The excitatory action was fully antagonized by icv 4 nmol D,L-2-amino-7-phosphonoheptanoic acid, a specific NMDA receptor antagonist. Excitatory effect induced by quinolinic acid is possibly mediated by excitatory amino acid receptors in locus coeruleus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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2-Amino-5-phosphonovalerate* / analogs & derivatives*
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Amino Acids / pharmacology*
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Animals
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Anticonvulsants / pharmacology*
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Electrophysiology
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Glutamates / pharmacology
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Locus Coeruleus / physiology*
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Male
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N-Methylaspartate / antagonists & inhibitors*
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Neurons / physiology
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Quinolinic Acids / antagonists & inhibitors*
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Rats
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Rats, Inbred Strains
Substances
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Amino Acids
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Anticonvulsants
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Glutamates
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Quinolinic Acids
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glutamic acid diethyl ester
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N-Methylaspartate
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2-Amino-5-phosphonovalerate
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2-amino-7-phosphonoheptanoic acid