Polyoma virus-associated progressive multifocal leukoencephalopathy after renal transplantation: regression following withdrawal of mycophenolate mofetil

Pediatr Transplant. 2011 Mar;15(2):E19-24. doi: 10.1111/j.1399-3046.2010.01368.x. Epub 2010 Sep 29.

Abstract

The 2008-released FDA safety report described a potential association between use of MMF and progressive multifocal leukoencephalopathy. We here report the case of an 11-yr-old kidney transplanted boy suffering from PML who showed rapid improvement parallel to withdrawal of MMF. This case contributes to the increasing knowledge on side effects of MMF treatment in children.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Follow-Up Studies
  • Humans
  • Immunocompromised Host
  • Immunosuppressive Agents / adverse effects*
  • Immunosuppressive Agents / therapeutic use
  • Kidney Failure, Chronic / genetics
  • Kidney Failure, Chronic / surgery*
  • Kidney Transplantation / adverse effects
  • Kidney Transplantation / immunology
  • Kidney Transplantation / methods
  • Leukoencephalopathy, Progressive Multifocal / etiology
  • Leukoencephalopathy, Progressive Multifocal / virology*
  • Male
  • Mycophenolic Acid / adverse effects
  • Mycophenolic Acid / analogs & derivatives*
  • Mycophenolic Acid / therapeutic use
  • Polyomavirus / immunology*
  • Polyomavirus Infections / complications
  • Polyomavirus Infections / immunology
  • Risk Assessment
  • Transplantation Immunology / drug effects
  • Tumor Virus Infections / complications
  • Tumor Virus Infections / diagnosis
  • Tumor Virus Infections / immunology*
  • Withholding Treatment

Substances

  • Immunosuppressive Agents
  • Mycophenolic Acid