Abstract
Regulatory T-cells (Treg) actively maintain immunological self-tolerance and play a significant role in the progression of cancer. Treg cell numbers have been evaluated in 80 patients with previously untreated chronic lymphocytic leukemia (CLL) and in 40 normal healthy volunteers. Treg cells are higher in CLL patients than in controls and correlate with disease status (more advanced clinical stage, peripheral blood B-cell lymphocytosis, absolute CD38+ B-cell number, and more elevated LDH levels). No correlation was found with ZAP-70 expression, IgVH mutational status and cytogenetic abnormalities. This data shows that Treg cell number is abnormal in CLL patients.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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ADP-ribosyl Cyclase 1 / blood
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Adult
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Aged
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Aged, 80 and over
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B-Lymphocytes / pathology*
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Biomarkers, Tumor / analysis*
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Case-Control Studies
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Chromosome Aberrations
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Disease Progression
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Female
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Humans
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Immunoglobulin Heavy Chains / genetics
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Immunoglobulin Variable Region / genetics
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics
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Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
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Male
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Middle Aged
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Mutation / genetics
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Prognosis
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Survival Rate
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T-Lymphocytes, Regulatory / immunology*
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ZAP-70 Protein-Tyrosine Kinase / metabolism
Substances
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Biomarkers, Tumor
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Immunoglobulin Heavy Chains
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Immunoglobulin Variable Region
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ZAP-70 Protein-Tyrosine Kinase
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ZAP70 protein, human
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ADP-ribosyl Cyclase 1