Molecular characterization of clinical methicillin-resistant Staphylococcus aureus isolates in South Africa

J Clin Microbiol. 2010 Dec;48(12):4608-11. doi: 10.1128/JCM.01704-10. Epub 2010 Sep 29.

Abstract

Eighty-two percent of 320 clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates from various infection sites collected throughout South Africa were separated into five major globally prevalent clusters by SmaI pulsed-field gel electrophoresis, spa, and SCCmec typing. Only one Panton-Valentine leukocidin-positive isolate was detected. This is the first detailed MRSA epidemiology study for the whole country.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacterial Toxins / genetics
  • Child
  • Child, Preschool
  • Cluster Analysis
  • Exotoxins / genetics
  • Female
  • Genotype
  • Humans
  • Infant
  • Infant, Newborn
  • Leukocidins / genetics
  • Male
  • Methicillin-Resistant Staphylococcus aureus / classification*
  • Methicillin-Resistant Staphylococcus aureus / genetics*
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification
  • Middle Aged
  • Molecular Epidemiology
  • Molecular Typing*
  • South Africa / epidemiology
  • Staphylococcal Infections / epidemiology*
  • Staphylococcal Infections / microbiology*
  • Virulence Factors / genetics
  • Young Adult

Substances

  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Panton-Valentine leukocidin
  • Virulence Factors