Abstract
ABCG2, which encodes an ATP-binding cassette transporter protein, is associated with the phenotype of cancer stem cells and is used to define the pluripotential side population cells by flow cytometry and slide-cytometry. MicroRNAs control a wide array of biological processes (e.g., cell differentiation, proliferation and apoptosis) whose dysregulation is a hallmark of cancer. MicroRNA-328 (miR-328) is underexpressed in many cancers including glioblastoma multiforme and contributes to tumor resistance to chemotherapy. ABCG2 is associated with multi-drug resistance and is also highly expressed in glioblastoma. Some preliminary studies have shown that ABCG2 is the target gene for miRNA-328. Thus, we hypothesize that modulating ABCG2 expression by targeting miRNA-328 in glioblastoma cancer stem cells could represent a promising strategy for therapeutic manipulation to increase the efficacy of chemotherapeutic agents for glioblastoma, a highly lethal type of cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP Binding Cassette Transporter, Subfamily G, Member 2
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ATP-Binding Cassette Transporters / biosynthesis
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ATP-Binding Cassette Transporters / genetics*
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ATP-Binding Cassette Transporters / metabolism
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology
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Brain Neoplasms / genetics*
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Brain Neoplasms / metabolism
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Down-Regulation / drug effects
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Drug Resistance, Multiple
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Drug Resistance, Neoplasm / genetics*
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Gene Expression
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Glioblastoma / genetics*
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Glioblastoma / metabolism
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Humans
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MicroRNAs / genetics*
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MicroRNAs / metabolism
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Neoplasm Proteins / genetics*
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Neoplasm Proteins / metabolism
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Neoplasms / genetics
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Neoplasms / metabolism
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Neoplasms / pathology
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Neoplastic Stem Cells / metabolism*
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Neoplastic Stem Cells / pathology
Substances
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ABCG2 protein, human
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ATP Binding Cassette Transporter, Subfamily G, Member 2
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ATP-Binding Cassette Transporters
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Antineoplastic Agents
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MicroRNAs
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Neoplasm Proteins