Abstract
AIDS‐associated Cryptococcus neoformans and Penicillium marneffei coinfection has not been adequately studied and poses unique therapeutic challenges in resource‐limited settings. Itraconazole poorly penetrates the central nervous system, whereas fluconazole has poor activity against P. marneffei. We prospectively report management of 1 patient and retrospectively review 7 coinfection cases from Vietnam.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / diagnosis*
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AIDS-Related Opportunistic Infections / drug therapy
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AIDS-Related Opportunistic Infections / microbiology
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Adult
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Antifungal Agents / pharmacokinetics*
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Antifungal Agents / therapeutic use*
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Cryptococcus neoformans / drug effects
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Cryptococcus neoformans / isolation & purification*
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Developing Countries
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Diagnosis, Differential
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Fluconazole / pharmacokinetics
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Fluconazole / therapeutic use
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Humans
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Itraconazole / pharmacokinetics
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Itraconazole / therapeutic use
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Male
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Mycoses / diagnosis*
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Mycoses / drug therapy*
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Mycoses / microbiology
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Penicillium / drug effects
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Penicillium / isolation & purification*
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Prospective Studies
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Retrospective Studies
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Vietnam
Substances
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Antifungal Agents
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Itraconazole
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Fluconazole