The yin and yang of polycomb repression in regenerating muscle

Gergana Dobreva; Thomas Braun

doi:10.1016/j.stem.2010.09.005

The yin and yang of polycomb repression in regenerating muscle

Cell Stem Cell. 2010 Oct 8;7(4):422-4. doi: 10.1016/j.stem.2010.09.005.

Authors

Gergana Dobreva¹, Thomas Braun

Affiliation

¹ Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Ludwigstr. 43, Germany.

PMID: 20887945
DOI: 10.1016/j.stem.2010.09.005

Abstract

Tumor necrosis factor-α (TNF-α) has complex effects on muscle regeneration. In this issue of Cell Stem Cell, Palacios et al. (2010) report that TNF-α-activated p38α kinase controls differentiation of muscle stem cells by promoting polycomb repressive complex 2 (PRC2) silencing of the Pax7 promoter.

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